师资队伍

李立亮
职称：
副教授
专业：
导师类型：
博士生导师
研究方向：
精神病人猝死的分子与遗传机制；不明原因猝死分型与鉴识
毕业院校：
复旦大学
邮箱地址：
liliang_li@fudan.edu.cn
个人简介

  1. Gao Pan*, Cao Mengying, Wang Xiaolin, Zhang Hongyuan, Chen Xuanlong, Song Ziyan, Zhang Molin, Li Lin, Yin Chao, Yuan Jie, Cai Shen, Wang Zening, Cao Zhonglian, Su Chen, Zhang Guoping, Komuro Issei, Ge Junbo, Li Liliang*, Zou Yunzeng*. G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice. Circulation. 2025 Sep 23;152(12):882-898.

  2. Chen Xuanlong, Ma Lu, Bo Yiming, Xia Bing, Guo Yadong, Shang Yanjie, Yan Fengping, Huang Erwen, Shi Weibo, Ding Runtao, Meng Hang, Xiao Bi, Ma Kaijun, Li Liliang*. Single-nucleus RNA sequencing and machine learning identify CACNA1A as a myocyte-specific biomarker for sudden unexplained death in schizophrenia. Forensic Sci Int. 2025 Dec: 377:112646.

  3. Song Ziyan, Bian Wensi, Lin Junyi, Guo Yadong, Shi Weibo, Meng Hang, Chen Yongsheng, Zhang Molin, Liu Zheng, Lin Zijie, Ma Kaijun*, Li Liliang*. Heart proteomic profiling discovers MYH6 and COX5B as biomarkers for sudden unexplained death. Forensic Sci Int. 2024 Aug; 361:112121.

  4. Wang Shouyu, Chen Yongsheng, Du Jianghua, Wang Zhimin, Lin Zijie, Hong Guanghui, Qu Dong, Shen Yiwen, Li Liliang*. Post-mortem genetic analysis of sudden unexplained death in a young cohort: a whole-exome sequencing study. Int J Legal Med. 2023 Nov;137(6):1661-1670.

  5. Gao Pan, Cao Mengying, Jiang Xueli, Wang Xiaolin, Zhang Guoping, Tang Xinru, Yang Chunjie, Komuro Issei, Ge Junbo*, Li Liliang*, Zou Yunzeng*. Cannabinoid Receptor 2-Centric Molecular Feedback Loop Drives Necroptosis in Diabetic Heart Injuries. Circulation. 2023 Jan 10; 147(2): 158-174.

  6. Zhang Molin, Wang Shouyu, Tang Xinru, Ye Xing, Chen Yongsheng, Liu Zheng, Li Liliang*. Use of potassium ion channel and spliceosome proteins as diagnostic biomarkers for sudden unexplained death in schizophrenia. Forensic Sci Int. 2022 Nov: 340:111471.

  7. Li Liliang#, *, Gao Pan#, Tang Xinru, Liu Zheng, Cao Mengying, Luo Ruoyu, Li Xiaoqing, Wang Jing, Lin Xinyi, Peng Chao, Li Zhihong, Zhang Jianhua, Zhang Xian, Cao Zhonglian, Zou Yunzeng*, Jin Li*. CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity. Sig Transd Target Ther, 2022 May.doi:10.1038/s41392-022-01018-7. (*co-corresponding authors, #co-first authors)

  8. Yu Bokang, Xu Chenchao, Tang Xinru, Liu Zheng, Lin Xinyi, Meng Hang, Shi Cheng, Ma Kaijun, Xiao Bi, Li Liliang*. Endoplasmic reticulum stress-related secretory proteins as biomarkers of early myocardial ischemia-induced sudden cardiac deaths. Int J Legal Med. 2022 Jan;136(1):159-168.

  9. Wang Jing, Li Xiaoqing, Liu, Zheng, Lin Xinyi, Zhong Fan, Li Shuhao, Tang Xinru, Zhang Yang, Li Liliang*.Second-generation antipsychotics induce cardiotoxicity by disrupting spliceosome signaling: Implications from proteomic and transcriptomic analyses. Pharmacol Res. 2021 Aug; 170:105714.

  10. Gao Pan#, Li Liliang#, Yang Liu*, Gui Dingkun, Zhang Jiarong, Han Junfeng, Wang Jiajia, Wang Niansong, Lu Junxi, Chen Suzhen, Hou Liping, Sun Honglin, Xie Liping, Zhou Jian, Peng Chao, Lu Yan, Peng Xuemei, Wang Cunchuan, Miao Ji, Ozcan Umut, Huang Yu, Jia Weiping*, Liu, Junli*. Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1.Science Transl Med. 2019 Sep 18;11(510): eaaw2050. (#co-first authors)


代表性论文

  1. Gao Pan*, Cao Mengying, Wang Xiaolin, Zhang Hongyuan, Chen Xuanlong, Song Ziyan, Zhang Molin, Li Lin, Yin Chao, Yuan Jie, Cai Shen, Wang Zening, Cao Zhonglian, Su Chen, Zhang Guoping, Komuro Issei, Ge Junbo, Li Liliang*, Zou Yunzeng*. G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice. Circulation. 2025 Sep 23;152(12):882-898.

  2. Chen Xuanlong, Ma Lu, Bo Yiming, Xia Bing, Guo Yadong, Shang Yanjie, Yan Fengping, Huang Erwen, Shi Weibo, Ding Runtao, Meng Hang, Xiao Bi, Ma Kaijun, Li Liliang*. Single-nucleus RNA sequencing and machine learning identify CACNA1A as a myocyte-specific biomarker for sudden unexplained death in schizophrenia. Forensic Sci Int. 2025 Dec: 377:112646.

  3. Song Ziyan, Bian Wensi, Lin Junyi, Guo Yadong, Shi Weibo, Meng Hang, Chen Yongsheng, Zhang Molin, Liu Zheng, Lin Zijie, Ma Kaijun*, Li Liliang*. Heart proteomic profiling discovers MYH6 and COX5B as biomarkers for sudden unexplained death. Forensic Sci Int. 2024 Aug; 361:112121.

  4. Wang Shouyu, Chen Yongsheng, Du Jianghua, Wang Zhimin, Lin Zijie, Hong Guanghui, Qu Dong, Shen Yiwen, Li Liliang*. Post-mortem genetic analysis of sudden unexplained death in a young cohort: a whole-exome sequencing study. Int J Legal Med. 2023 Nov;137(6):1661-1670.

  5. Gao Pan, Cao Mengying, Jiang Xueli, Wang Xiaolin, Zhang Guoping, Tang Xinru, Yang Chunjie, Komuro Issei, Ge Junbo*, Li Liliang*, Zou Yunzeng*. Cannabinoid Receptor 2-Centric Molecular Feedback Loop Drives Necroptosis in Diabetic Heart Injuries. Circulation. 2023 Jan 10; 147(2): 158-174.

  6. Zhang Molin, Wang Shouyu, Tang Xinru, Ye Xing, Chen Yongsheng, Liu Zheng, Li Liliang*. Use of potassium ion channel and spliceosome proteins as diagnostic biomarkers for sudden unexplained death in schizophrenia. Forensic Sci Int. 2022 Nov: 340:111471.

  7. Li Liliang#, *, Gao Pan#, Tang Xinru, Liu Zheng, Cao Mengying, Luo Ruoyu, Li Xiaoqing, Wang Jing, Lin Xinyi, Peng Chao, Li Zhihong, Zhang Jianhua, Zhang Xian, Cao Zhonglian, Zou Yunzeng*, Jin Li*. CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity. Sig Transd Target Ther, 2022 May.doi:10.1038/s41392-022-01018-7. (*co-corresponding authors, #co-first authors)

  8. Yu Bokang, Xu Chenchao, Tang Xinru, Liu Zheng, Lin Xinyi, Meng Hang, Shi Cheng, Ma Kaijun, Xiao Bi, Li Liliang*. Endoplasmic reticulum stress-related secretory proteins as biomarkers of early myocardial ischemia-induced sudden cardiac deaths. Int J Legal Med. 2022 Jan;136(1):159-168.

  9. Wang Jing, Li Xiaoqing, Liu, Zheng, Lin Xinyi, Zhong Fan, Li Shuhao, Tang Xinru, Zhang Yang, Li Liliang*.Second-generation antipsychotics induce cardiotoxicity by disrupting spliceosome signaling: Implications from proteomic and transcriptomic analyses. Pharmacol Res. 2021 Aug; 170:105714.

  10. Gao Pan#, Li Liliang#, Yang Liu*, Gui Dingkun, Zhang Jiarong, Han Junfeng, Wang Jiajia, Wang Niansong, Lu Junxi, Chen Suzhen, Hou Liping, Sun Honglin, Xie Liping, Zhou Jian, Peng Chao, Lu Yan, Peng Xuemei, Wang Cunchuan, Miao Ji, Ozcan Umut, Huang Yu, Jia Weiping*, Liu, Junli*. Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1.Science Transl Med. 2019 Sep 18;11(510): eaaw2050. (#co-first authors)


代表性著作


获奖

获得人才项目：

国家优秀青年科学基金


获得奖项：

2024，上海医学科技奖三等奖（第一完成人）

2024，复旦大学青年五四奖章

2024，中国心血管病基础领域十大研究进展

2024，复旦大学第一三共制药奖教金

2023，第十一届全国药物毒理学大会优秀论文奖

2023, 司法鉴定理论与实践研讨会优秀论文奖

2022，第十六届东方心脏病学会优秀论文二等奖

2022，第十三届全国大学生“挑战杯”创业计划大赛上海市银奖（指导老师）

2021，欧洲毒理学会Gerhard-Zbinden青年科学家奖提名

2021，第十五届东方心脏病学会议优秀论文二等奖

2021，第七届全国大学生基础医学创新研究暨实验设计大赛铜奖（指导教师）

2020，复旦大学基础医学院青年教师教学比赛三等奖

2019，中国毒理学会年度优秀论文奖

2019，上海市司法鉴定协会司法鉴定文书比赛一等奖

2019，上海市司法鉴定协会阅片比赛二等奖

2019，首届全国法医学青年教师教学比赛三等奖

2019，复旦大学上海医学院MBBS教师教学比赛三等奖